Recent achievements in REPRODUCTIVE biomedicine have led to a revolution in infertility treatment. A comprehensive understanding of the current status of REPRODUCTIVE medicine is necessary for the development of a forward-looking plan by health policymakers, based on fundamental requirements. This study is a systematic review of the Scopus database to assess REPRODUCTIVE biomedicine publications within Iran and compared to the rest of the world from 1990 to 2020. The data were categorized by geographical distribution across five continents. National data were assessed in comparison with the world and with neighboring countries. Finally, prominent national research institutes in the field of REPRODUCTIVE biomedicine in Iran were identified, and their contributions to the field highlighted. Of the five continents, the highest number of publications and citations is from Europe (36% publications and 41. 5% citations). Corresponding numbers for the other continents are 32 and 33% for America, and 26 and 18. 4% for Asia respectively. The remaining publications and citations were from Australia (3. 8 and 4. 1%) and Africa (2. 6 and 3. 1%). In a national analysis, the highest-ranking institutes in REPRODUCTIVE biomedicine are in Tehran province (50. 9% of all Iranian publications), Shiraz (8. 8%), Yazd (7. 8%), Isfahan (7. 1%), and Tabriz (6. 9%). More specifically, Tehran University of Medical Science (15. 9%), the Royan Institute (12. 2%), Shahid Beheshti Medical University (10. 1%), Shahid Sadoughi University of Medical Sciences (6. 9%), and Tarbiat Modares University (6. 7%) account for more than 50% of all Iranian scientific publications. In recent decades, REPRODUCTIVE biomedical research has grown significantly in Iran. Reviewing publications in this field helps health policy decision makers to monitor the direction of research and adjust investment in the treatment of infertility. In addition, it is necessary to expand and organize inter-organizational and international collaborations to improve the research, gain the benefits of different experiences, and engage in international multicenter studies.